Rhythm Plus

The Rhythm Plus™ hormone test is a comprehensive salivary assessment of estradiol, progesterone, and testosterone that spans a full 28 days. Additionally, this hormone testing profile includes the Adrenocortex Stress Profile and the Comprehensive Melatonin Profile to reveal how the sex hormones are influenced by cortisol, DHEA, and melatonin. Hormonal balance is the key. Fluctuating levels of estradiol, progesterone, and testosterone play a major role in a woman's overall health. Rhythm Plus is a hormonal test indicated for both premenopausal and perimenopausal women not currently supplementing with hormones.

Hormone imbalances may be responsible for:

  • Menstrual cycle irregularities

  • Mood disorders

  • Insomnia

  • GI complaints

  • Libido

  • Fatigue

The Rhythm Plus provides a thorough analysis of estradiol and progesterone over a full 28 day cycle. Testosterone is measured once from the 28th day specimen. By utilizing 11 saliva samples for analysis, the relationship and balance of these essential hormones are analyzed more precisely through time. The levels of estradiol and progesterone, as well as the ratio between the two, are clearly graphed for easy reference and patient education.

As part of the Rhythm Plus™ profile, clinicians have several cortisol testing options, each offering its own level of clinical insight:
  • Adrenocortex Stress Profile (ASP): Four salivary samples measured throughout the day to give insight into the natural circadian diurnal cortisol rhythm, and help clinicians address specific daily stressors.

  • Cortisol Awakening Response (CAR): Three awakening samples to evaluate CAR with one evening cortisol sample.

    • CAR is a transient, immediate rise in cortisol upon awakening and is distinct from the diurnal rhythm. CAR reflects a person's ability to cope with anticipated challenges and their perception of control around chronic stress, providing insight into HPA axis resiliency.

    • The isolated evening cortisol has distinct clinical implications. Elevated evening cortisol is linked to insomnia and associated with various diseases such as diabetes, cardiovascular disease, hormonally driven cancers, and osteoporosis.

  • Adrenocortex Stress Profile with Cortisol Awakening Response (ASP with CAR): Six samples that offers the most comprehensive look at cortisol and the HPA axis.

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Based on NSA's ongoing commitment to quality assurance, we have updated the calculation for CAR to reflect a direct percentage increase. Most literature demonstrates an expected increase of ≥ 50% (with a range of 50 -150%).

Test Type: Saliva Test

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