Menopause Plus

The Most Comprehensive Salivary Hormone Test for Hormone-Related Conditions

Menopause Plus™ is our most comprehensive salivary hormone test for evaluating key hormone levels in both women and men. Eight specimens – collected over six days – are examined for levels of estradiol, estrone, estriol, progesterone, the progesterone/estradiol ratio (P/E2), and testosterone. In addition to thorough evaluation of the sex hormones, Menopause Plus also evaluates DHEA, cortisol, and melatonin for the broadest scope of clinical insight.

To enhance clinical utility, in addition to evaluating patient results against various healthy cohort reference ranges, a therapeutic cohort results cover page is provided for the clinician to quickly and conveniently observe where patient results fall in comparison to a cohort of peri/menopausal women treated with bioidentical hormone therapy.

The Menopause Plus hormone test provides information about the impact that shifting hormone levels can have in women during perimenopause and menopause and in men during andropause (male menopause). In addition, imbalances of other steroid hormones, such as DHEA, cortisol, and melatonin, can influence sex-hormone production. Hormones imbalances can be associated with common symptoms such as:

  • Hot flashes

  • Fatigue

  • Weight loss or gain

  • Menstrual irregularities

  • Loss of libido

  • Changes in hair and skin

The Menopause Plus salivary assessment offers several advantages for patients presenting with hormone-related symptoms:

  • Comprehensive testing: eight saliva samples, collected every other day over 6 days, provides individual and average levels for estrone (E1), estradiol (E2), estriol (E3), progesterone, progesterone/estradiol ratio (P/E2), as well as a one-time measurement of testosterone; additional collections over a 24-hr period provide diurnal measurement of cortisol, DHEA, and melatonin

  • Reporting: reference and therapeutic ranges enabling the physician to choose the optimal reference cohort for their patient

  • Patient ease-of-use: saliva testing is simple, non-invasive and at-home collection

Imbalanced hormone production affects a wide range of body functions, producing symptoms that can negatively affect the quality of life. Identification and targeted treatment of hormonal imbalances using customized hormone therapy, targeted nutritional supplementation and/or diet/lifestyle recommendations can improve symptoms and enhance quality of life.

To meet the individual needs of patients and clinical objectives, NSA offers two additional salivary hormone tests in the Menopause series, with varying collection time frames and specimen requirements.

As part of the Menopause Plus™, clinicians have several cortisol testing options, each offering its own level of clinical insight:
  • Adrenocortex Stress Profile (ASP): Four salivary samples measured throughout the day to give insight into the natural circadian diurnal cortisol rhythm, and help clinicians address specific daily stressors.

  • Cortisol Awakening Response (CAR): Three awakening samples to evaluate CAR with one evening cortisol sample.

    • CAR is a transient, immediate rise in cortisol upon awakening and is distinct from the diurnal rhythm. CAR reflects a person's ability to cope with anticipated challenges and their perception of control around chronic stress, providing insight into HPA axis resiliency.

    • The isolated evening cortisol has distinct clinical implications. Elevated evening cortisol is linked to insomnia and associated with various diseases such as diabetes, cardiovascular disease, hormonally driven cancers, and osteoporosis.

  • Adrenocortex Stress Profile with Cortisol Awakening Response (ASP with CAR): Six samples that offers the most comprehensive look at cortisol and the HPA axis.

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Based on NSA's ongoing commitment to quality assurance, we have updated the calculation for CAR to reflect a direct percentage increase. Most literature demonstrates an expected increase of ≥ 50% (with a range of 50 -150%).

Test Type: Saliva Test

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